Helicobacter pylori is a micro-aerophilic, Gram-negative, slow-growing, spiral-shaped and flagellated organism. pylori have revolutionized our view of the gastric environment, the diseases associated with it, and the appropriate treatment regimens 2. However, this discovery and subsequent studies on H. The discovery 1 that Helicobacter pylori was associated with gastric inflammation and peptic ulcer disease was initially met with scepticism. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH.įor most of this century the cause of peptic ulcer disease was thought to be stress-related and the disease to be prevalent in hyperacid producers. pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. pylori, like several other mucosal pathogens, probably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenic variation and adaptive evolution. Based on the large number of sequence-related genes encoding outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding sequences, H. Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host–pathogen interaction. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Nature volume 388, pages 539–547 ( 1997) Cite this article The complete genome sequence of the gastric pathogen Helicobacter pylori
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